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463 Colchicine has been shown to alter the expression of proteins on the surfaces of endothelial cells, white blood cells, and platelets, which may interfere with their ability to participate in thrombosis

Thioredoxin reductase 1 (TXNRD1) is predominantly located in the cytoplasmic lysis and contains a catalytically essential selenocysteine residue at its C-terminal active site

Moreover, PCA seemed to downregulate the level of ferroptosis in the colon tissue, evidenced by a reduced iron overload, decreased GSH depletion, and a lower level of MDA production, whereas similar results were observed in Erastin-treated Caco-2 cells

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By day 37, the left ventricular diastolic diameter was also enlarged, accompanied by progressive thinning of the interventricular septum and posterior wall